RESUMO
This study evaluates the contribution of peripheral biomarkers to comorbidities and clinical findings in autism. Seventeen autistic children and age-matched typically developing (AMTD), between three to nine years old were evaluated. The diagnostic followed the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DMS-IV) and the Childhood Autism Rating Scale (CARS) was applied to classify the severity. Cytokine profile was evaluated in plasma using a sandwich type ELISA. Paraclinical events included electroencephalography (EEG) record. Statistical analysis was done to explore significant differences in cytokine profile between autism and AMTD groups and respect clinical and paraclinical parameters. Significant differences were found to IL-1ß, IL-6, IL-17, IL-12p40, and IL-12p70 cytokines in individuals with autism compared with AMTD (p < 0.05). All autistic patients showed interictalepileptiform activity at EEG, however, only 37.5% suffered epilepsy. There was not a regional focalization of the abnormalities that were detectable with EEG in autistic patients with history of epilepsy. A higher IL-6 level was observed in patients without history of epilepsy with interictalepileptiform activity in the frontal brain region, p < 0.05. In conclusion, peripheral inflammatory markers might be useful as potential biomarkers to predict comorbidities in autism as well as reinforce and aid informed decision-making related to EEG findings in children with Autism spectrum disorders (ASD).
RESUMO
El autismo constituye una problemática compleja, enigmática y continúa siendo un reto, con el objetivo de precisar algunas alteraciones cognitivas en relación al lenguaje presentes en un grupo de niños autistas se realizó este trabajo de tipo descriptivo y de corte transversal. La investigación fue realizada en la Escuela Especial para niños con Autismo Dora Alonso en Ciudad de la Habana, Cuba, en el período comprendido de Septiembre 2008 a Julio 2009. La muestra quedo representada por 29 niños diagnosticados como autistas primarios con edades cronológicas de ≥ 5 años ≤ a los 9 años de edad. Predominó el sexo masculino en una proporción 2,6:1. A los mismos se les aplicó, el inventario de dimensiones del espectro autista de Ángel Reviere (I.D.E.A) .El 86,2 por ciento de los niños matricularon en la escuela antes de los 5 años. La totalidad de los niños estudiados tuvieron algún trastorno de las funciones comunicativas, del lenguaje expresivo y receptivo las formas más graves se presentaron en el sexo femenino(AU)
Autism is being a complex, enigmatic problem and a challenge. This descriptive and transversal work was developed with the aim of determining some cognitive disorders that a group of Autistic children present. The research was done at Dora Alonso Special School for Autism located in Ciudad de la Habana, Cuba, from Septembre 2008 to July 2009. The studied group has 29 children, between 5 and 9 years of age.Predominate male sex in a 2,6:1 proportion .The students were applied the dimensión inventory of Angel Reviere (I.D.E.A) Autistic spectrum. The majority (86,2 percent) were enrolled at the school before the age of 5.The totality of studied children had some disorders of comunicatives functions ,receptive and expressive language. Girls presented the worst results(AU)
Assuntos
Humanos , Masculino , Feminino , Criança , Transtorno Autístico/complicações , Transtorno Autístico/prevenção & controle , Comunicação , Transtornos da Comunicação/diagnóstico , Transtornos da Comunicação/psicologia , Transtornos da Linguagem/diagnóstico , Transtornos da Linguagem/psicologia , Epidemiologia Descritiva , Estudos TransversaisRESUMO
Se realizó una investigación descriptiva y transversal con el objetivo de conocer la prevalencia de trastornos gastrointestinales, en dos grupos de niños uno autista y otro no autista El universo de trabajo se constituyo por los niños autistas matriculados oficialmente en la Escuela Especial de Autismo Infantil Dora Alonso del Municipio Marianao, y por los niños sanos pertenecientes al Consejo Popular Armada del Municipio Cerro, la muestra se obtuvo mediante un muestreo al azar (edades y sexos homogéneos), en el periodo comprendido de Enero-Diciembre de 2009. Se estudiaron 36 niños y 12 niñas por grupo. El número de niños con presencia de síntomas digestivos, fue significativamente mayor en el grupo de niños autistas que en el de controles(AU)
A transversal and descriptive investigation was carried out with the objective of knowing the prevalence of gastrointestinal disorders in two groups of children ,one with autistic disorder and other without it. The universe of work was constituted by the autistic children which were registerd officially enrolled at Dora Alonso Special Infant School of Autism located in the municipality of Marianao (the sample coincided with the study work) and with healthy children of Armada People´s Council of Cerro municipality (the sampling was done at random with homogeneous ages and sex) from January to December 2009.36 boys were studied and 12 girls per group. The number of boys with presence of digestive sintomes were significantly greater in the group of autistic boy than in the one of controles(AU)
